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KMID : 0350519930460041683
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Journal of Catholic Medical College
1993 Volume.46 No. 4 p.1683 ~ p.1698
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Effects of Interleukin-6 on Corneal Epithelial Wound Closure after Exoimer Laser Surface Ablation in Rabbits
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Abstract
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To evaluate the effects of interleukin-6(IL-6) on epithelial migration in corneal epithelial wound healing process after 193 nm excimer laser surface ablation(35㎛ in depth and 6 mm in diameter), the morphologic changes as well as the healing
rate
of
the defect area were observed on 30 rabbits (60 eyes). The animal were devided into three groups of twnty each : the control group and the two IL-6 treated groups (dropping with 0.1 mg/1 and 1.0 mg/l IL-6).
@ES The findings were as follows :
@EN 1. On light microscopic examination, no significan difference in morphology was observed until 9 hours among all three groups. After 9 hours, However, centripetal migration of epithelial cells and covering of bare stroma with monolayered
epithelial
cells were more remarkable in the 1.0 mg/l group than in the control group, reaching the peak at 18 hours. The changes of the 0.1 mg/l group were rather similar to those of the control proup.
2. On transmission electron microscopic examination after 18 hours, the 1.0 mg/l group showed the ioss of hemidesmosome beneath the leading edge of sliding epithelial cells other intracellular structures were well preserved.
3. On scanning electron microscopic examination, epithelial migration started at 9 hours in all three groups and the epitheiial migration was more rapid in the 1.0 mg/l group than in the control group.
4. The reduction of epithelial defect area of excimer laser surface ablation showed no significant difference until 9 hours in all three groups. 15 hours and afterwards, however, the healing rate was significantly accelerated in the 1.0 mg/l
group
than
in the control group. The healing rates were 0.91㎟/hr, 0.92㎟/hr, 1.0㎟/hr in the control group, 0.1mg/l group respectively.
In view of the above findings, it was speculated that IL-6 could be used effectively in the early treatment of excimer laser keratectomy, and other corneal epithelial injury.
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